Protein Purification Reagents and Kits
AdipoGen SARS-CoV-2 S1 RBD His
Recombinant protein. Receptor-binding domain RBD of SARS-CoV-2 Spike protein S1 aa 319-541 is fused at the C-terminus to a His-tag. Binds to anti-SARS-CoV-2 Spike RBD antibodies in serum or plasma. Endotoxin <0.01EU/µg purified protein LAL test. Lyophilized. Contains PBS. SARS-CoV-2 shares 79.5% sequence identity with SARS-CoV and is 96.2% identical at the genome level to the bat coronavirus BatCoV RaTG133, suggesting it had originated in bats. The coronaviral genome encodes four major structural proteins the Spike S protein, Nucleocapsid N protein, Membrane/Matrix M protein and the Envelope E protein. The SARS Envelope E protein contains a short palindromic transmembrane helical hairpin that seems to deform lipid bilayers, which may explain its role in viral budding and virion envelope morphogenesis. The SARS Membrane/Matrix M protein is one of the major structural viral proteins.
Genscript Corporation BTN3A1/CD277Biotin His Av
The three butyrophilin BTN3A molecules BTN3A1 BTN3A2 and BTN3A3 are members of the B7/butyrophilin-like group of Ig superfamily receptors which modulate the function of T cells BTN3A1 controls activation of human V 9/V 2 T cells by direct or indirect presentation of self and nonself phosphoantigens (pAg)
![eMolecules 90914-41-3 | Pharmablock | 3-bromo-4-chloro-1h-pyrazolo[34-d]pyrimidine | 50mg | 551135875 | PBN20120598 | MFCD08276165 | 233.45 | C5H2BrClN4](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502517659.JPG-250.jpg)
eMolecules 90914-41-3 | Pharmablock | 3-bromo-4-chloro-1h-pyrazolo[34-d]pyrimidine | 50mg | 551135875 | PBN20120598 | MFCD08276165 | 233.45 | C5H2BrClN4
Pharmablock | 3-bromo-4-chloro-1h-pyrazolo[34-d]pyrimidine | 50mg | 551135875 | PBN20120598 | 90914-41-3 | MFCD08276165 | 233.450 | C5H2BrClN4
![eMolecules 1140241-22-0 | 2-CHLORO-4-METHYL-5H-PYRROLO[3,2-D]PYRIMIDINE | AstaTech | MFCD11869950 | 167.600 | C7H6ClN3 | 95.000 | Cc1nc(Cl)nc2cc[nH]c12 | 0.25g | 364324607](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502477419.JPG-250.jpg)
eMolecules 1140241-22-0 | 2-CHLORO-4-METHYL-5H-PYRROLO[3,2-D]PYRIMIDINE | AstaTech | MFCD11869950 | 167.600 | C7H6ClN3 | 95.000 | Cc1nc(Cl)nc2cc[nH]c12 | 0.25g | 364324607
2-CHLORO-4-METHYL-5H-PYRROLO[3,2-D]PYRIMIDINE | AstaTech | 1140241-22-0 | MFCD11869950 | 167.600 | C7H6ClN3 | 95.000 | Cc1nc(Cl)nc2cc[nH]c12 | 0.25g | 364324607
![eMolecules 900514-10-5 | 5-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine | Pharmablock | MFCD08688599 | 262.026 | C7H4FIN2 | 97.000 | Fc1cnc2[nH]cc(I)c2c1 | 25mg | 673359717](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502435122.JPG-250.jpg)
eMolecules 900514-10-5 | 5-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine | Pharmablock | MFCD08688599 | 262.026 | C7H4FIN2 | 97.000 | Fc1cnc2[nH]cc(I)c2c1 | 25mg | 673359717
5-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine | Pharmablock | 900514-10-5 | MFCD08688599 | 262.026 | C7H4FIN2 | 97.000 | Fc1cnc2[nH]cc(I)c2c1 | 25mg | 673359717
Cayman Chemical 5-fluoro nI 5mg
A derivative of NNEI in which a fluorine atom has been added to the terminal carbon of the pentyl chain; intended for forensic and research applications
Medchemexpress LLC PROTAC B-Raf degrader 1 | 2364367-27-9 | 99.8% | 763.77 | 1 MG
PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity.
- Can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system.
- Affects the expression of Mcl-1, a downstream protein of B-Raf.
- Induces apoptosis in MCF-7 cells, with an apoptosis rate of 76.70% (64.00% early apoptosis, 12.70% late apoptosis) after 24 h incubation at 20 μM.
- Arrests cell cycle at the G2/M phase.
Cayman Chemical GST Sample Buffer2X 1ea
An alkaloid with anti-inflammatory activity reduces LPS-induced TNF-a release from and NO production in RAW 264.7 macrophages at 10 30 and 100 UM reduces paw swelling in a rat model of CFA-induced arthritis at 9 and 27 mg/kg reduces colonic inflammatory cytokine levels and maintains mucosal barrier function in a mouse model of DSS-induced colitis from 25-100 mg/kg
Medchemexpress LLC RAS/RAS-RAF-IN-1 | 2447039-81-6 | 99.8% | 807.98 | 1 MG
RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor that exhibits antitumor activity. It demonstrates a KD of 5.0 μM-15 μM for cyclophilin A (CYPA) binding affinity. This compound is intended for research use only.
- Potent RAS and RAS-RAF inhibitor
- Exhibits antitumor activity
- Has a KD of 5.0 μM-15 μM for cyclophilin A (CYPA) binding affinity
- Shows EC50 of 0.5 μM-5.0 μM for BRAF-GTP-KRAS-G12C disruption in H358 cells
- Demonstrates IC50 of 1.0 μM-10 μM for pERK inhibition in H358 cells
- For research use only
Meso Scale Discovery R-PLEX Human -GST ASYQP
The R-PLEX Human Alpha GST Assay Kit from Meso Scale Discovery measures alpha glutathione S-transferase (GSTA1) in human serum plasma and other samples It uses MSD s electrochemiluminescent detection for high sensitivity a dynamic range of up to 5 logs and low sample volume The kit includes a 96-well plate with capture antibodies detection antibodies calibrators controls 10X Read Buffer 10X Wash Buffer and Plate Seals It quantifies alpha GST levels between 0 04 - 500 ng/mL with just 25 L of sample enabling accurate quantitation of the liver toxicity biomarker alpha GST
American Research Products Inc Mouse glutathione peroXidase
Mouse glutathione peroXidase (GSH-PX) ELISA Kit from CUSABIO Detection Range 31 25 U/mL-2000 U/mL Sensitivity 7 8 U/mL Sample serum plasma tissue homogenates Method Sandwich
AdipoGen ANGPTL3 FLD h rec
Recombinant Protein. Fibrinogen-like domain of human ANGPTL3 aa 224-460 is fused at the N-terminus to a FLAG -tag. Source/Host HEK 293 cells. Endotoxin <0.01EU/µg purified protein LAL test. Lyophilized. Contains PBS. ANGPTL3 Angiopoietin-like protein 3 regulates angiogenesis and also directly regulates lipid, glucose and energy metabolism. Angiopoietin-like 3 ANGPTL3 is a regulator of plasma triglyceride TRG levels due to its inhibitory action on the activity of lipoprotein lipase LPL. ANGPTL3 induces angiogenesis by binding to integrin alphavbeta3. ANGPTL3 is predominantly produced in the liver and can therefore be classified as a hepatokine. In the human plasma, ANGPTL3 is cleaved to released two fragments a N-terminal coiled-coil domain-containing fragment aa17-207 important for inhibiting the lipolysis of triglyceride and the C-terminal fibrinogen-like domain-containing fragment aa208-460.